This book is about the nature of skeptical arguments and their role in philosophical inquiry. John Greco delineates three main theses: that a number of historically prominent skeptical arguments make no obvious mistake, and therefore cannot be easily dismissed; that the analysis of skeptical arguments is philosophically useful and important, and should therefore have a central place in the methodology of philosophy; and that taking skeptical arguments seriously requires us to adopt an externalist, reliabilist epistemology. This book will be of interest to professionals and graduate students in epistemology and moral philosophy.